Highly enantioselective zinc/BINOL-catalyzed alkynylation of α-ketoimine ester: a new entry to optically active quaternary α-CF3 α-amino acids.
نویسندگان
چکیده
An effective method for highly enantioselective alkynylation of ketoimine (α-trifluoromethyl ketoimine ester) has been developed via a zinc/BINOL catalyzed process. This protocol provides a useful and facile access to optically active quaternary α-trifluoromethyl α-amino acids and related derivatives of interest in life sciences.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 47 19 شماره
صفحات -
تاریخ انتشار 2011